For over 25 years, the founder and team at Klotho Skin have been studying the regenerative properties of the Klotho gene for implementation to skincare. Klotho Skin is dedicated to continuing research with the Klotho Protein and the benefits it offers.

GROWTH FACTORS

Fibroblast, otherwise known as skin cells, are one of the first cells to respond to wound healing by secreting communication signals termed growth factors (GFs) to signal cellular proliferation and repair. As we age, the body produces a lower amount of fibroblast cells and growth factors which inhibits the body’s ability to defend itself against UV radiation and harmful environmental factors. Exposure to extreme environments, stress, poor nutrition, lack of sleep and causes free- radical damage and increased oxidative stress on a cellular level.

KLOTHO GENE

The Klotho gene is expressed in many tissues and cell types, and its over-expression in mammals extends lifespan due to its ability to mimic the caloric restriction pathway of cells. Further, the Klotho protein activates the FOXO forkhead transcription factors that are negatively regulated by insulin/IGF-1 signaling, which then facilitates oxidative stress resistance and directly protects cells from UVA and UVB radiation. In all, because of Klotho’s ability to inhibit IGF-1 signaling and increase FOX01, cells develop increased resistance to oxidative stress as well as longevity and anti-ageing characteristics. Klotho expression declines by 60% in aging skin cells.

We work with adult mesenchymal stem cells derived from fat and genetically alter them to upregulate the klotho gene. Stem cells secrete what is known as cell conditioned medium. Because the klotho gene is upregulated in our stem cells, we get the Kltoho protein and second generation growth factors in our cell conditioned medium.This cell conditioned medium makes up 25% of our Face Serum, 15% of our Eye Serum and 10% of our night cream.

Klotho Skin is the first skin care line to genetically modify adult mesenchymal stem cells to increase the Klotho protein and second-generation growth factors.

Klotho is an age-suppressing gene and protein that supports cell renewal and wound repair. The Klotho protein and second-generation factors make up 25% of the cell-conditioned medium in our face serum, 15% for our eye serum and 10% for our night cream and may be preventative, protective, and restorative.

Our formula is encapsulated in liposomal (fat-soluble) cells, allowing for the ingredients to overcome cellular absorption barriers and increase bioavailability.

Klotho Skin products stimulate Klotho gene expression and assist the skin in developing more collagen, decreasing the breakdown of existing collagen, and decreasing TEWL (transepidermal water loss). Further, we are able to initiate an anti-inflammatory process and the reversal of oxidative stress to skin cells, creating the appearance of younger and healthier skin.