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A proprietary blend of Second Generation Growth Factors, biomimetic peptides and other symbiotic ingredients provides anti-aging protection and a renewed youthful radiance to the eye area.


Daily use promotes cellular expression of Klotho gene:

  • Increased collagen production, smoothing out fine and habitual lines
  • Decreased collagen breakdown, slowing the loss of volume under the eye area as well as the development of fine lines and wrinkles
  • Decreased TEWL (Transepidermal Water Loss), increasing skin firmness
  • Increase oxidative stress protection, deflecting cell damage and visible signs of aging
  • Increased anti-inflammatory responses, promoting healthy skin tone



After cleansing and drying face, twist the cap of bottle to dispense serum onto clean hands. Gently pat serum into the skin in a circular motion. Wait 5 minutes for serum to dry and absorb before applying any moisturizer or sunblock.

Best results are seen when applied morning and night. All skin care products should be used for 21 to 28 days prior to evaluation to ensure full cell cycle results.



Klotho Skin ingredients are clean, sustainably sourced, and proven effective. All ingredients in Klotho Skin products are sustainably sourced. Klotho Skin products are responsibly packaged, using minimal plastics. Klotho Skin products are cruelty free, with absolutely no animal testing practices.


Klotho Skin is formulated for all skin types and all ages from clean, sustainably sourced, and proven ingredients: EGF (oligopeptide-1), Vitamin E, Glycerine, Squalene, Acetyl Hexapeptide-8, Hesperidin Methyl Chalcone Dipeptide-2, Palmitoyl Tetrapeptide-7, Chrysin, N-Hydroxysuccinimide, Palmitoyl hexapeptide-12 Aminoethylphosphonic Acid, Caprylyl Glycol, Sorbitol, Sodium Hyaluronate, Butylene Glycol, Xanthan Gum, 1,2-Hexanediol, Lactic Acid, Fruit Oil Extract.

Klotho Skin 28-Day Before & After gallery for proven results.

KLOTHO SKINCARE + What is the difference between serum and cream/moisturizer? Serums are highly concentrated anti-aging ingredients. Unlike moisturizers, they do not contain occlusive, or airtight, ingredients such as petrolatum or mineral oil that create a barrier on your skin. Because serums do not contain filler ingredients, they penetrate the skin faster and more effectively, requiring minimal amounts of product per application. Klotho Skin developed a liposome delivery system for its products to allow growth factor proteins that normally could not penetrate the epidermis to reach their target areas. The proprietary technology encodes the product and mimics a transporting fat molecule to allow GF entry and breakdown. + What causes fine lines and wrinkles around my eyes? Dependent upon your age and skin type, fine lines typically appear around the eyes as signs of dehydration. Over time, the lines become permanent as signs of habitual movements, and moisture and collagen loss through oxidative stress. The Klotho Skin formula increases the body's natural sodium dioxide levels, resulting in cellular protection against oxidative stress. + What is TEWL (Transepidermal Water Loss)? TEWL is the process in which water passes from the dermis (middle layer) to the epidermis (outer layer) and evaporates from the skin’s surface. While TEWL is a process that your skin naturally regulates, certain circumstances such as injury, low-humidity weather conditions and topically applied products can damage the skin’s barrier function can dry out the skin and affect TEWL levels. + At what age should I begin applying eye serum? Klotho Skin recommends starting an eye serum at age 20, to encourage hydration and delay or prevent fine lines under the eyes. + Is it too late to use an eye serum? It is never too late to take care of your skin. The active ingredients in Klotho Skin products work on all skins, at all ages. KLOTHO DECONSTRUCTED + What are Human Fibroblasts? Fibroblasts are the main connective tissues found in the body. A fibroblast cell is responsible for building the extracellular matrix (a framework that supports additional structures) and collagen (the element that fills the framework). Together, the matrix and collagen form the structural framework of tissues and play an important role in tissue repair. As the fibroblast ages , collagen production drops almost in half. Klotho Skin uses Klotho enhanced cells to produce special cell conditioned medium containing second generation growth factor and the Klotho protein. These factors are then isolated and harvested to set the framework for Klotho activation and its resultant benefits. + What are biomimetic peptides? Peptides are short chains of two or more amino acids that play a number of roles in skin repair and function, including facilitating cellular communication and collagen production. Biomimetic peptides are lab-created amino acid chains that mimic the effects of naturally-occurring peptides. Through the use of specifically designed and targeted biopeptides, Klotho Skin is able to target receptor cells and encourage the activation of the Klotho gene within them. + Are Klotho Skin products fragrance free? Klotho Skin uses plant essential oils within its ingredient list. Hints of fruit oil extracts can be recognized. + Were animals tested in the making of this product? No animals were used for testing in the making of Klotho Skin products. VIEW STUDIES